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Anti-Hu CD261 Purified Low Endotoxin
Catalog Number: orb154420
| Catalog Number | orb154420 |
|---|---|
| Category | Antibodies |
| Description | Mouse monoclonal antibody to CD261 which is a receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to activated CD261 which is expressed in most human tissues including spleen, peripheral blood leucocytes, thymus and in a variety oFT tumour-derived cell lines. It plays a role in inducing cell death. The binding oFT TRAIL to DR4 triggers the activation oFT pro-caspases 8 and 10, leading to apoptosis. |
| Clonality | Monoclonal |
| Clone Number | DR-4-02 |
| Tested applications | FA, FC, ICC, IP |
| Reactivity | Human |
| Isotype | Mouse IgG1 |
| Immunogen | Fusion protein containing the extracellular part of TRAIL-R1 and the constant part of the heavy chain of the human IgG1. |
| Antibody Type | Primary Antibody |
| Concentration | 1 mg/ml |
| Purity | Purified by protein-A affinity chromatography. |
| Conjugation | Unconjugated |
| Target | CD261 |
| Entrez | 8797 |
| UniProt ID | O00220 |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Buffer/Preservatives | Phosphate buffered saline (PBS), pH 7.4 |
| Alternative names | Anti-DR4 antibody, anti-APO2 antibody, anti-TNFRSF Read more... |
| Note | For research use only |
| Application notes | Low Endotoxin, Azide free format. Product does not contain preservatives and is intended primarily for functional applications. Preservative containing buffers are available for IHC applications |
| Expiration Date | 12 months from date of receipt. |
Flow cytometry analysis of TRAIL-R1 expression on the surface of hematopoietic cell lines. Cells were stained with purified anti-TRAIL-R1 purified antibodies (low endotoxin) followed by Goat anti-mouse IgG PE.
