Anti-ERBB2 / HER2 / CD340 Reference Antibody (pertuzumab)

• Catalog Number: orb1818441
• Category: Antibodies
• Description: Recombinant Antibody
• Clonality: Monoclonal
• Tested applications: ELISA, FC
• Reactivity: Human, Mouse, Rat
• Isotype: IgG1
• Antibody Type: Primary Antibody
• Concentration: 1mg/ml
• Form/Appearance: Purified monoclonal antibody supplied in PBS, pH 6.0, without preservative.This antibody is purified through a protein A column.
• Conjugation: Unconjugated
• MW: 145.44
• UniProt ID: P04626
• Protein Sequence: ERBB2 / HER2 / CD340
• Expression System: CHO Cell
• Endotoxins: < 0.001EU/μg,determined by LAL method.
• Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
• Alternative names: Receptor tyrosine-protein kinase erbB-2, 2.7.10.1,
• Note: For research use only
• Expiration Date: 12 months from date of receipt.

The purity of Anti-ERBB2 / HER2 / CD340 Reference Antibody (pertuzumab) is more than 99.02%, determined by SEC-HPLC.

Immobilized human HER2 (23 652) His at 2 µg/mL can bind Anti-ERBB2 / HER2 / CD340 Reference Antibody (pertuzumab), EC50=0.01375 µg/mL

Anti-ERBB2 / HER2 / CD340 Reference Antibody (pertuzumab) on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 95%

Pertuzumab+trastuzumab inhibited the tumor growth of NCI-N87 on Balb/c nude mice. The result showed significant anti-tumor effects, with an tumor inhibition rate (TGI) of 73.8% at 5 mpk at D37.

BT474 cells were stained with Anti-ERBB2 / HER2 / CD340 Reference Antibody (pertuzumab) and negative control protein respectively, washed and then followed by PE and analyzed with FACS, EC98=0.2994 µg/mL