Anti-BCMA bispecific antibody(DM4)

• Catalog Number: orb1826963
• Category: Antibodies
• Description: Anti-BCMA bispecific antibody(DM4)
• Species/Host: Rabbit
• Clonality: Monoclonal
• Clone Number: DM4
• Tested applications: FC
• Reactivity: Human
• Isotype: Rabbit scfv
• Dilution range: Flow Cyt 1:100; MMTumor cell killing
• Conjugation: Unconjugated
• Target: BCMA
• UniProt ID: Q02223
• Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
• Alternative names: TNFRSF17
• Note: For research use only
• Application notes: Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions of reconstitution.
• Expiration Date: 12 months from date of receipt.

The basic principle of BiTE cell killing assay. The BiTE molecule can effectively bring T cells to tumor target cells and stimulate tumor cell killing activity of T cells.

A: The scheme of Anti-BCMA BiTE molecule. B: Tumor cell killing assay. NCI-H929 cells (stably transfected with luciferase), were incubated with freshly isolated human PBMC, and different concentration of BiTE antibodies constructed from rabbit Anti-Human BCMA/TNFRSF17 Clone DM4 (red line), or BB2121 originated huC11D5.3 clone (blue line) or a no BCMA binding clone as negative control (black line). After 48hrs incubation, the viable NCI-H929 tumor cells were measured by luciferase activity assay.