(Aminooxy)acetamide-Val-Cit-PAB-MMAE

• Catalog Number: orb2279054
• Category: Small Molecules
• Description: (Aminooxy)acetamide-Val-Cit-PAB-MMAE
• CAS Number: 2446645-88-9
• MW: 1196.48
• SMILES: [C@H]([C@H](C(N[C@@H]([C@@H](O)C1=CC=CC=C1)C)=O)C)(OC)[C@]2(N(C(C[C@H]([C@@H](N(C([C@@H](NC([C@@H](N(C(OCC3=CC=C(NC([C@@H](NC([C@@H](NC(CON)=O)[C@@H](C)C)=O)CCCNC(N)=O)=O)C=C3)=O)C)C(C)C)=O)[C@@H](C)C)=O)C)[C@H](CC)C)OC)=O)CCC2)[H]
• Formula: C₆₀H₉₇N₁₁O₁₄
• Biological Activity: (Aminooxy)acetamide-Val-Cit-PAB-MMAE (MMAE 5) serves as an intermediate for synthesizing drug-linker conjugates in antibody-drug conjugates (ADCs). This compound is first conjugated to a polyamide through oxime bond formation, resulting in an MMAE polyamide conjugate. Subsequently, the MMAE polyamide conjugate is attached to Trastuzumab to create the ADC [1].
• Note: For research use only
• Expiration Date: 12 months from date of receipt.