AMG-548

• Catalog Number: orb1710450
• Category: Small Molecules
• Description: AMG-548
• CAS Number: 864249-60-5
• Purity: 98%
• MW: 461.56
• SMILES: O=C1C(=C(N=C(NC[C@H](CC2=CC=CC=C2)N)N1C)C=3C=CN=CC3)C4=CC5=C(C=C4)C=CC=C5
• Formula: C₂₉H₂₇N₅O
• Biological Activity: AMG-548 is an orally active and selective p38α inhibitor (Ki=0.5 nM), shows slightly selective over p38β (Ki=36 nM) and > 1000 fold selective against p38γ and p38δ and is also extremely potent in the inhibition of whole blood LPS stimulated TNFα (IC50=3 nM)[1]. AMG-548 inhibits Wnt signaling by directly inhibiting Casein kinase 1 isoforms δ and ε[2].
• Storage: -20°C
• Note: For research use only
• Expiration Date: 12 months from date of receipt.