AMG-548 dihydrochloride

• Catalog Number: orb1686275
• Category: Small Molecules
• Description: AMG-548 dihydrochloride
• Purity: 98%
• MW: 534.48
• Formula: C₂₉H₂₉Cl₂N₅O
• Biological Activity: AMG-548 dihydrochloride is a selective, orally active p38α inhibitor with a Ki value of 0.5 nM, a slight selectivity for p38β (Ki=36 nM) and > 1000-fold selectivity for p38γ and p38δ. AMG-548 dihydrochloride exhibits inhibition of whole blood LPS-stimulated TNFα with an IC50 value of 3 nM. AMG-548 dihydrochloride directly inhibited casein kinase 1 isoforms δ and ε, and inhibited Wnt signaling.
• Note: For research use only
• Expiration Date: 12 months from date of receipt.