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Catalog Number | orb1304336 |
---|---|
Category | Small Molecules |
Description | AM-2394 |
CAS Number | 1442684-77-6 |
Purity | 99.58% |
MW | 423.46 |
SMILES | CNC(=O)Nc1cc(Oc2cncc(C)c2)c(cn1)-c1ccc(OCC(C)(C)O)nc1 |
Formula | C22H25N5O4 |
Biological Activity | AM-2394 is an effective and specific Glucokinase agonist (GKA, EC50: 60 nM), which catalyzes the phosphorylation of glucose to glucose-6-phosphate. AM-2394(AM2394) increases the affinity of GK for glucose by approximately 10-fold, exhibits moderate clearance and good oral bioavailability in multiple animal models, and lowers glucose excursion following an oral glucose tolerance test in an ob/ob mouse model of diabetes. |
Storage | -20°C |
Note | For research use only |
Expiration Date | 12 months from date of receipt. |
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