Alofanib

• Catalog Number: orb1302071
• Category: Small Molecules
• Description: Alofanib
• CAS Number: 1612888-66-0
• Purity: 99.53%
• MW: 413.4
• SMILES: N(S(=O)(=O)C1=CC(C(O)=O)=CC=C1)C2=C(N(=O)=O)C=C(C)C(=C2)C=3C=CC=NC3
• Formula: C₁₉H₁₅N₃O₆S
• Biological Activity: Alofanib is a selective allosteric inhibitor of FGFR2 and has a dramatic inhibitory effect on FGF2-induced phosphorylation of FRS2a in KATO III cells (IC50 < 10 nM). It has no direct effect on FGF2-dependent FGFR1 and FGFR3 phosphorylation levels in either cell lines and no effects on FGF2-FGFR2 binding.
• Storage: Store at -20°C for 12 months.
• Note: For research use only
• Expiration Date: 12 months from date of receipt.