AKI603

• Catalog Number: orb692001
• Category: Small Molecules
• Description: AKI-603 is a novel small molecule Aurora A kinase inhibitor with IC50 of 12.3 nM, also inhibits Aurora B kinase activity to a less extent; disrupts normal spindle structure, and induces cell-cycle arrest; t; suppresses stem cell properties in breast cancer cells, and also suppresses the expression of self-renewal genes (β-catenin, c-Myc, Sox2, and Oct4); reduces xenograft tumor growth after intragastric administration.
• CAS Number: [1432515-73-5]
• MW: 409.454
• SMILES: CC1=CC(=NN1)NC2=CC(=NC(=N2)NC3=CC=C(C=C3)[N+](=O)[O-])N4CCN(CC4)C
• Formula: C₁₉H₂₃N₉O₂
• Note: For research use only
• Expiration Date: 12 months from date of receipt.