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Catalog Number | orb1302854 |
---|---|
Category | Small Molecules |
Description | A-674563 HCl (552325-73-2(free base)) |
CAS Number | 2070009-66-2 |
Purity | 99.69% |
MW | 394.9 |
Formula | C22H23ClN4O |
Biological Activity | A-674563 is an orally available, ATP-competitive, and reversible inhibitor of Akt (Ki: 11 nM for Akt1) [1]. It exhibits inhibitory activity against PKA and Cdk2 (IC50: 16/46 nM) but is 10- to > 1, 800-fold selective for Akt1 versus additional kinases in the CMGC, CAMK, and TK families [1]. |
Storage | Store at -20°C for 12 months. |
Note | For research use only |
Expiration Date | 12 months from date of receipt. |
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