A-674563 HCl (552325-73-2(free base))

• Catalog Number: orb1302854
• Category: Small Molecules
• Description: A-674563 HCl (552325-73-2(free base))
• CAS Number: 2070009-66-2
• Purity: 99.69%
• MW: 394.9
• SMILES: CC=1C=2C(=CC=C(C2)C=3C=C(OC[C@H](CC4=CC=CC=C4)N)C=NC3)NN1.Cl
• Formula: C₂₂H₂₃ClN₄O
• Biological Activity: A-674563 is an orally available, ATP-competitive, and reversible inhibitor of Akt (Ki: 11 nM for Akt1) [1]. It exhibits inhibitory activity against PKA and Cdk2 (IC50: 16/46 nM) but is 10- to > 1, 800-fold selective for Akt1 versus additional kinases in the CMGC, CAMK, and TK families [1].
• Storage: -20°C
• Note: For research use only
• Expiration Date: 12 months from date of receipt.