A-674563 2HCl(552325-73-2(fb-2hcl))

• Catalog Number: orb1219449
• Category: Small Molecules
• Description: A-674563 is an Akt1 inhibitor with Ki of 11 nM, modest potent to PKA and > 30-fold selective for Akt1 over PKC.A-674563 reduces phosphorylation of Akt downstream targets in cells and slows proliferation of tumor cells in vitro (EC50: 0.4 μM) [1]. A563 (0-10 μM) markedly decreases GSK3 and MDM2 phosphorylation in STS cells.
• CAS Number: ——
• Purity: > 98% (HPLC)
• MW: 431.4
• Formula: C₂₂H₂₄Cl₂N₄O
• Target: Akt1|CDK2|PKA|ERK2|PKCδ
• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Note: For research use only
• Expiration Date: 12 months from date of receipt.