3-Methylthienyl-carbonyl-JNJ-7706621

• Catalog Number: orb1984475
• Category: Small Molecules
• Description: 3-Methylthienyl-carbonyl-JNJ-7706621
• CAS Number: 443798-09-2
• MW: 378.43
• SMILES: Cc1ccsc1C(=O)n1nc(Nc2ccc(cc2)S(N)(=O)=O)nc1N
• Formula: C₁₄H₁₄N₆O₃S₂
• Biological Activity: 3-Methylthienyl-carbonyl-JNJ-7706621 is a highly potent and selective inhibitor of cyclin-dependent kinase (CDK). It exhibits impressive IC50 values of 6.4 nM and 2 nM for CDK1/cyclin B and CDK2/cyclin A, respectively. Additionally, 3-Methylthienyl-carbonyl-JNJ-7706621 demonstrates potent inhibition against GSK-3 (IC50 = 0.041 μM) and moderate potency towards CDK4, VEGF-R2, and FGF-R2 (IC50 = 0.11 μM, 0.13 μM, and 0.22 μM, respectively). Its applications in cancer research are noteworthy.
• Note: For research use only
• Expiration Date: 12 months from date of receipt.