(2Z,3Z)-U0126

• Catalog Number: orb1739654
• Category: Small Molecules
• Description: U-0126
• CAS Number: 218601-62-8
• Purity: 0.98
• MW: 380.49
• SMILES: C(/C(=C(/SC1=C(N)C=CC=C1)\N)/C#N)(=C(\SC2=C(N)C=CC=C2)/N)\C#N
• Formula: C₁₈H₁₆N₆S₂
• Biological Activity: (2Z,3Z)-U0126 is a highly selective inhibitor of both MEK1 and MEK2, a type of MAPK/ERK kinase. It was found to functionally antagonize AP-1 transcriptional activity via noncompetitive inhibition of the dual specificity kinase MEK with IC50 of 72 nM for MEK1 and 58 nM for MEK2. U0126 inhibited anchorage-independent growth of Ki-ras-transformed rat fibroblasts by simultaneously blocking both extracellular signal-regulated kinase and mammalian target of rapamycin pathways.
• Note: For research use only
• Expiration Date: 12 months from date of receipt.