1,3,5-Trihydroxy-4-prenylxanthone

• Catalog Number: orb1689954
• Category: Small Molecules
• Description: 1,3,5-Trihydroxy-4-prenylxanthone
• CAS Number: 53377-61-0
• Purity: 98%
• MW: 312.32
• SMILES: C(C=C(C)C)C1=C2C(C(=O)C=3C(O2)=C(O)C=CC3)=C(O)C=C1O
• Formula: C₁₈H₁₆O₅
• Biological Activity: 1,3,5-Trihydroxy-4-prenylxanthone is a relatively potent inhibitor of phosphodiesterase type 5 (PDE5), with an IC50 value of 3.0 μM; it shows in vitro inhibitory activity against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), with IC50 values of 56.3plusmn;0.4 and 46.0plusmn;0.3 M, respectively. 1,3,5-Trihydroxy-4-prenylxanthone inhibits LPS-induced NF-κB and AP-1 activations by interfering with the posttranslational modification (phosphorylation and/or ubiquitinylation) of IRAK-1 in the cell membrane to impede TAK1-mediated activation of IKK and MAPKs signal transduction.
• Storage: -20°C
• Note: For research use only
• Expiration Date: 12 months from date of receipt.