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Catalog Number | orb1689954 |
---|---|
Category | Small Molecules |
Description | 1,3,5-Trihydroxy-4-prenylxanthone |
CAS Number | 53377-61-0 |
Purity | 98% |
MW | 312.32 |
SMILES | C(C=C(C)C)C1=C2C(C(=O)C=3C(O2)=C(O)C=CC3)=C(O)C=C1O |
Formula | C18H16O5 |
Biological Activity | 1,3,5-Trihydroxy-4-prenylxanthone is a relatively potent inhibitor of phosphodiesterase type 5 (PDE5), with an IC50 value of 3.0 μM; it shows in vitro inhibitory activity against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), with IC50 values of 56.3plusmn;0.4 and 46.0plusmn;0.3 M, respectively. 1,3,5-Trihydroxy-4-prenylxanthone inhibits LPS-induced NF-κB and AP-1 activations by interfering with the posttranslational modification (phosphorylation and/or ubiquitinylation) of IRAK-1 in the cell membrane to impede TAK1-mediated activation of IKK and MAPKs signal transduction. |
Storage | -20°C |
Note | For research use only |
Expiration Date | 12 months from date of receipt. |
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