1-Hydroxy-2,3,5-trimethoxyxanthone

SKU: orb1683981

Description

1-Hydroxy-2,3,5-trimethoxyxanthone (HM-1) is a multi-target small molecule exhibiting vasodilation via NO-dependent and Ca²⁺ channel-blocking mechanisms. It inhibits osteoclast differentiation in co-culture models and shows protective effects in murine LPS-induced acute lung injury by modulating IκB-α, iNOS, and COX-II expression. This compound is a useful research tool for cardiovascular, bone metabolism, and inflammation studies.

Research Area

Immunology & Inflammation, Metabolism Research, Neuroscience, Pharmacology & Drug Discovery, Signal Transduction

Key Properties

• CAS Number: 22804-49-5
• MW: 302.28
• Formula: C₁₆H₁₄O₆
• SMILES: COc1cc2oc3c(OC)cccc3c(=O)c2c(O)c1OC
• Target: IκB/IKK,COX,NOS,5-HT Receptor,Calcium Channel

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

5318372